THE EFECT OF SMOKING IN PARATHYROID HORMONE (PTH) AND ALKALINE PHOSPHTASE (ALP)
Noora Faroug , Elhashimi E. Hassan*, Nassr Eldin M.A.Shrif , Siham M.Bakhit
ABSTRACT
Background: Smoking is one of the most common practices and
believed to be associated with decreased bone density and calcium
absorption therefore abnormalities of both PTH and ALP are expected
in smokers. Objectives: This study was aimed to study the effect
smocking in serum levels of PTH and ALP activity in comparison to
healthy non-smokers. Methods: this is a cross-sectional study
conducted during the period from August to December 2011. Blood
samples were drawn from 50 apparently healthy cigarette smokers’
volunteers (as test group) and 50 apparently healthy non smokers’
volunteers’ age, BMI and gender matched as control group. Serum
levels of parathyroid hormone and ALP activity was analysed for both groups by using
commercial reagent kits from DRG diagnostic and commercial reagent kits from Bio system
Company by Selector E, respectively. Data were analysed using SPSS v 16. Results: The
serum level of PTH in smokers (14.174±5.89 pg/ml) was significantly decreased than nonsmokers
(26.874±11.8627 pg/ml) , p.value <0.0001. The activity of ALP was significantly
increased in smokers compared to non-smokers (119.24±31.2 vs 89.70±20.28 u/l , p.value <
0.0001). In test group serum parathyroid hormone was negatively correlated,while alkaline
phosphatase activity was positively correlated with both the duration of smoking (per
years)and the number of cigarette smoked per day. Conclusion: From this study, it is
concluded that; cigarette smoking is associated with low serum parathyroid hormone and
increased serum alkaline phosphates activity and more alteration is expected with both
increased duration of smoking per year and number of cigarettes smoked per day
Keywords: Background: Smoking is one of the most common practices and believed to be associated with decreased bone density and calcium absorption therefore abnormalities of both PTH and ALP are expected in smokers. Objectives: This study was aimed to study the eff
[Download Article]
[Download Certifiate]