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Abstract

GREEN SYNTHESIS AND CARDIOPROTECTIVE ACTIVITY OF NYCTANTHUS ARBOR-TRISTIS ZNO NANOPARTICLE AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS

*Haripriya S. and Sudhakar P.

ABSTRACT

Myocardial infarction is a life-threatening condition that occurs when blood flow to the heart is abruptly cut off, thereby causing tissue damage. The leaves of the Nyctanthus arbor-tristis mainly used in ayurvedic, siddha, unani. Because of the presence of more potent oleanolic acid in the leaves, the hydrochloric extract was therefore investigated for its cardioprotective activity in Nano-form. The present study was therefore aimed for Green synthesis and cardioprotective activity of Nyctanthus arbor-tristisZnO Nanoparticle against Isoproterenol induced myocardial infarction in rats. Thirty Albino Wister male rats weighing 200-300gm were randomly assigned to groups, each group containing six animals. I-Control, II- Negative control, III-Standard, IV-HAE-NAT, V-ZnO NP-NAT. Myocardial infarction was induced by intra peritoneal injection of Isoproterenol 85mg/kg in two consecutive dose on 14th and 15th day. In this study, ZnO NP against isoproterenol induced animals exhibited significant induced in serum total cholesterol TG, LDL level and decrease in HDL. And also serum cardiac activity markers CK-MB, LDH,ALT,AST and ALP were elevated. It might be concluded Hydroalcoholic extract of nyctanthus arbor tristis in cardioprotective activity which might be aid to reduce the myocardial infarction, cardioprotective effect of ZnO NP was proved by reduction in cardiac markers, altered lipid profile and histopathological studies.

Keywords: Nanoparticle, Isoproterenol, cardioprotective, Green synthesis ZnO NP.


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