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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF PRAZIQUANTEL IN TABLET FORMULATION

Uma Parvathy S.*, Dhivya K. and Parvathi S.

ABSTRACT

Praziquantel is a drug which is used in the treatment of Helminthics caused by Tape worm & Roundworm. A simple, rapid, selective UV spectrophotometric method was developed for the estimation of praziquantel in tablet dosage form. The method was based on the measurement of maximum absorbance at about 261 nm wavelength of praziquantel using methanol as a solvent. The linearity studies indicated that estimation of praziquantel obeys beer’s law at the concentration of 250mcg to 750mcg/ml. This method was validated in terms of accuracy, precision and specificity as per ICH Q2 (R1) guidelines. The percentage recovery range was found between 99.61-100%, that indicates the good index of precision and accuracy. Thus, this proposed method was found to be specific, precise, and cost-effective quality control tool for the routine analysis of praziquantel in tablet dosage form.

Keywords: Praziquantel, UV spectrophotometric, validation, Precision.


[Full Text Article]

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