WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SUSCEPTIBILITY OF MULTIDRUG RESISTANT GRAM-NEGATIVE BACTERIA TO FOSFOMYCIN

B. N. Vasudha Kowshik* and Sumana M. N.

ABSTRACT

The troubling rise in antibiotic resistance rates recorded for different pathogens led to the use of alternative treatment policies. The reassessment of older antibiotics is now an interesting choice, given the fairly restricted supply of new antimicrobial drugs.[1] Fosfomycin, a bactericidal analog of phosphoenolpyruvate that has previously been employed as an oral treatment for uncomplicated urinary tract infection, has recently raised interest among physicians worldwide.[3] In general, the advanced resistance identified in Gram-negative bacteria indicates that in patients with highly resistant microbial infections, fosfomycin may be an effective treatment of choice. This study focuses on the possibility of expanding the use of fosfomycin beyond urinary tract infections and against Gram-negative multidrug-resistant bacteria.[4] Objectives:- To evaluate the in-vitro activity of fosfomycin against multi drug resistant gram negative Bacterial isolates. Methodology:- The study was conducted prospectively in the Department of Microbiology of a tertiary care hospital from January 2019 to December 2019. A total of 100 multi-drug resistant isolates of E-coli, Klebsiella pneumonia, Acinetobacter baumannii, Enterobacter cloacae were collected from the patients admitted to a tertiary care hospital Mysuru, Karnataka. These isolates were subjected to fosfomycin susceptibility testing methods by disk diffusion & agar dilution method & the two methods were compared. Result:- 100 multidrug resistant gram-negative isolates were tested for susceptibility to fosfomycin. Of the 100 isolates of multidrug resistance(by disk diffusion & vitek 2 identification) there were 27 isolates from PUS , 16 isolates from SPUTUM, 29 isolates from ENDOTRACHEAL ASPIRATE, 17 isolates from URINE, 8 isolates from BLOOD, 1 isolate from URINARY CATHTER TUBE, 1 isolate from THROAT SWAB, 1 isolate from BILE. In the present study, we obtained fosfomycin susceptibilitiy 73 were sensitive out of 100 isolates, 8 were intermediate & 19 were resistant. Among 100 isolates 80.39% (41 out of 51) in K.pneumoniae, 60.52% (23 out of 38) A.baumannii, 88.88% (8 out of 9) in E.coli & 100% (1 out of 1) in A.lowfii were sensitive to fosfomycin. Conclusion:- Fosfomycin is effective against multidrug resistant gram negative bacteria.

Keywords: .


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More