Abstract

FORMULATION AND CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIER BASED NANOGEL FOR TOPICAL DELIVERY OF CLARITHROMYCIN

Ashwini Sable*, Prof. Trusha Shangrapawar and Dr. Ashok Bhosale

ABSTRACT

A Nanostructured lipid carrier (NLC) of Clarithromycin was prepared with the objective of treating acne and other skin infections. The Nanostructured Lipid Carriers was prepared by High Pressure Homogenization Method. In this study we formulated four different formulations of Nanostructured lipid carriers (NLC1, NLC2, NLC3, and NLC4) with different solid lipid (Stearic acid) to liquid lipid (oleic acid) ratios by homogenization and followed by lyophilisation. The NLC dispersion was found to be stable with lipid ratios 7:3 (Stearic acid: Oleic acid). Optimization of formulation was carried out on the basis of in-vitro dissolution, entrapment efficiency and drug loading capacity of all four batches NLC1, NLC2 NLC3, NLC4. The NLC4 formulation showed better dissolution rate, entrapment efficiency & drug loading capacity than other batches, thus we selected NLC4 batch for further study i.e. FTIR, DSC, XRD & Particle size, SEM, Zeta potential. It was concluded that formulated NLC holds as a potential approach for controlled release of drug which may reduce the dose frequency and improves patient compliance. By using NLC 4 batch we formulated three batches of Nanogel which has labelled as NG1, NG2, NG3 using different concentration of gelling agent (Carbopol 940p) & Triethanolamine. NLC based gels were characterized for pH, viscosity, spreadability, drug content and drug release study. From this study we found that the NG1 was better pH, spreadability, drug content, drug release than other batches. Thus optimized formulation (NG1) enhanced the permeation, sustains the drug release & enhanced the drug release at the site of action.

Keywords: Nanostructured lipid carriers; Clarithromycin; Hot homogenization technique; types of NLC; Nanotechnology.