Abstract

MODULATION OF PHARMACEUTICAL AND PHARMACOKINETIC ATTRIBUTE OF CURCUMIN ENCAPSULATED IN CHITOSAN USING SPRAY DRYING TECHNIQUE

Babitha V.*, Shafura S., Jayanthi C. and Hanumanthachar K. Joshi

ABSTRACT

Curcumin, a yellow polyphenol extracted from the rhizomes of turmeric (Curcuma longa), has been extensively used in China, India and southeast tropical Asia as a food spice, colouring agent and in the treatment of wide spectrum of ailments including biliary disorders, hepatic disorders, diabetic wounds, anorexia, rheumatism, sinusitis cancer and viral infections. Chitosan is a natural linear poly cationic polysaccharide obtained by partial N-deacetylation of chitin. It has many advantages as a carrier in nano particulate drug delivery system. It is nontoxic, biocompatible and biodegradable and has been proven to control the release of drugs, proteins and peptides. Spray-drying offers the advantages of producing a dry drug-loaded particle from polymer/drug solution in a single step. Several reports have demonstrated the feasibility of spray-drying chitosan for drug delivery formulations. This study were to assess the in vivo release of curcumin from nano curcumin prepared by Ionic cross linking method using sodium tripolyphosphate successfully entrapped curcumin, exhibiting higher encapsulation efficiency of 96.24%. Optimized nano particulate formulation exhibited the mean size of 10±0.1nm and the zeta potential found to be -100 mV. FTIR and DSC profiles revealed the probable and possible interactions of curcumin and casein in the nano formulation. Formulations exhibited very low dissolution in Simulated Gastric fluid (SGF) & Simulated Intestinal fluid (SIF).

Keywords: Curcumin, Chitosan, Nano particles, Tween 80, Spray drying.