Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2020 Issue has been successfully launched on 1 November 2020

Abstract

DEVELOPMENT AND VALIDATION OF RP-HPLC FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND ALOGLIPTIN IN BULK AND COMBINED TABLET DOSAGE FORM

*Kalyani Gudadhe, Bhagyashri Borade, Neha Deshmukh Mukund Tawar and Sagar Wankhade

ABSTRACT

A rapid, sensitive and accurate method for simultaneous estimation of Metformin and Alogliptin in drug product by liquid chromatography. The chromatographic separation was achieved on C18(ymc) (250X4.6mm,5.0).The separation achieved employing a mobile phase consists of 70%Methanol: 30%Water (0.1%OPA). The flow rate was 0.7ml/ minute and ultraviolet detector range at 250nm. The average retention time for Metformin and Alogliptin was found to be 4.279min and 6.023 min. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for S Alogliptin was performed on (05-20μg/ml) and for Metformin (10-60μg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively.

Keywords: RP-HPLC, Methanol, OPA, Metformin, Alogliptin.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More