WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

PHYTOCHEMICAL INVESTIGATION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF THE ROOT EXTRACTS OF RUTA CHALEPENSIS

Zelalem Abdisa* and Temesgen Ababu

ABSTRACT

Objective: Ruta chalepensis is an evergreen shrub that belongs to the family Rutaceae and reported to have antibacterial, anti-rheumatic, repellent activity, antioxidant activities and also traditionally used for treatment of snake bites, headaches and wounds. The objective of the present work was to study the chemical constituents, antibacterial and antioxidant activities of the root of Ruta chalepensis. Method: The powdered root of Ruta chalepensis was successively extracted using n-hexane, chloroform, acetone and methanol. Phytochemical screening was conducted using standard procedures. Antibacterial activity was evaluated against four human pathogenic bacteria namely Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhimurium using the agar disc diffusion technique. The DPPH radical scavenging assay was employed to test the antioxidant activity of the plant. Isolation of compound was performed using silica gel column chromatographic method. Result: Phytochemical screening test revealed the presence of alkaloids, flavonoids, saponins, tannins, phenolic compounds and glycosides in the root of Ruta chalepensis. The maximum inhibition zone (20 mm) was exhibited by acetone extract followed by chloroform extract (18 mm), both against Escherichia coli compared to Gentamicin (28 mm) indicating the significance of this plant against bacteria. The methanol crude extract inhibited DPPH by 94% at 0.5 mg/ml showing the potential of this plant as a natural antioxidant. The chloroform extract after silica gel column chromatographic separation has led to isolation of one pure furanocoumarin derivative, named 6-(2-methylbut-3-en-2-yl)-7H-furo[3,2-g]chromen-7-one (Chalepensin).

Keywords: Chalepensin, Radical scavenging activity, Rutaceae, Ruta chalepensis.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More