Abstract

HYPO: A DATABASE OF HYPOTHETICAL HUMAN PROTEINS

Prasanna Roy*, Soumitra Sahana, Debmalya Ghosh, Prasit Roy, Souvik Ghosal, lndranil Chatterjee, Suman Kumar Nath and Snehansu Biswas

ABSTRACT

All annotated genes were once hypothetical or uncharacterized. Keeping this as an conclusion, we have increased our former database of suppositional proteins (HP) in human (HypoDB) with added annotation, application programming interfaces and narrative features. Thedatabase hosts 1000+ manually curated records of the known „unknown‟ regions in the human genome. There are genes whose function remains unclear because they may not be the same as what is known in genetics. Such 'unknown' genes that make up the Open Reading Frames (ORF) left in the epigenome are referred to as orphan genes and the proteins they are involved in but have no experimental translation evidence called 'Hypothetical Proteins' (HPs). Complete HP collections tested using certified sets of tests (from Switzerland-Prot) or untested set (TrEMBL) or complete set (UniProtKB). The website is designed for Java in the main backendend, combined with details, that is. EMBL, PIR, HPRD and those that include structural details, communications and information details. HypoDB creates Application Programming Interfaces (API) for fully searchable resources that link them to other information such as NCBI Link-out in addition to multiple search capabilities and advanced search using integrated bio tools. The game with BLAST was included.

Keywords: Hypothetical, Open Reading Frames (ORF), Hypothetical Proteins (HPs), Genome, Application Programming Interfaces (API).