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Abstract

ANTIMICROBIAL METABOLITES’ PRODUCING BACTERIA FROM NIGERIAN WASTE TO WEALTH SITES

*Adegoke, Anthony Ayodeji and Adewumi Funmilayo A.

ABSTRACT

Microbes recovered from waste dumping sites in Lagos, Nigeria were screened for the production of novel antimicrobials. The best antimicrobial metabolite producer was thereafter identified by 16S rRNA sequencing techniques. Nine of the bacteria showed activity against at least one of the test reference strains. The best antibiotic producing bacteria (isolate DS-7A) exhibited mean inhibition zones of 8 ± 1.2 mm, 15 ± 0.61 mm, 23 ± 1.6 mm, 20 ± 2.20 mm and 22 ± 0.6 mm against E. coli ATCC BAA 2340, E. coli ATCC BAA 2326, Staphylococcus aureus ATCC 700699, Enterococcus faecalis ATCC 51299 and Bacillus cereus ATCC 14579 respectively. The least MICs of the purified compound and erythromycin (a standard antibiotic) were 25 μg/mL and 75 μg/mL against E. coli ATCC BAA 2340 and Bacillus cereus ATCC 14579 respectively. Glycerol and ammonium sulphate were the best carbon and nitrogen sources respectively for the potential novel isolate DS-7A. The optimum condition of pH and temperature for highest antimicrobial activity was observed to be 7 and 35 ºC respectively. The DS-7A isolates was identified as Streptomyces sp. Anthony DS-7A (Accession number: KU951662). This Streptomyces sp. Anthony DS-7A produced metabolites that showed wider spectrum of activities than previously reported species.

Keywords: Antimicrobial metabolites, Streptomyces sp., Bacillus cereus ATCC 14579, dump sites.


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