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Abstract

SYNTHESIS AND ANTI-INLFAMMATORY ACTIVITY OF SOME 3-SUBSTITUTED THIAZOLYL AND OXAZOLYL INDOLE DERIVATIVES

Vibha C Patil*, Kishore P Bhusari & Pramod B Khedekar

ABSTRACT

Research on indole revealed that esterification and amidation of the carboxylic acid moiety generates potent and selective cox-II inhibitors. This strategy helps us to broden the scope of neutralizing the carboxylic acid group to generate more potential indole derivatives. The cyclization and N-Acylation using acetyl chloride in presence of dry chloroform of compound 3-chloroacetyl indole with thoiurea and urea gave the respective thiazolyl and oxazolyl indoles, which were then treated with different aldehydes by cross-aldol condensation in presence of base (sodium hydroxide) gave the 3-substituted derivatives of thiazole indoles and oxazol indoles.

Keywords: Anti-inflammatory activity, thiazolyl indole derivatives, oxazolyl indole derivatives, antiinflammatory activity


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