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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFUROXIME AXETIL AND LINEZOLID IN COMBINED DOSAGE FORM

Santosh V. Gandhi*, Neha Sali, Shivam Jaiswal, Vipul Fegade and Vinod Gaikgwad

ABSTRACT

The present work deals with simple spectrophotometric method development for simultaneous estimation of Cefuroxime axetil and Linezolid in bulk and in two component tablet formulation. The methods developed were first derivative spectroscopy method and area under curve method. Methanol was used as solvent throughout the analysis. Regression analysis of beers plot showed good correlation in the range of 5-30 μg/ml for Cefuroxime as well as for Linezolid. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The method is validated as per ICH guidelines. The proposed method was successfully applied for determination of these drugs in formulation.

Keywords: UV-Spectrophotometry, Cefuroxime, Linezolid, Validation.

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