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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF TERBUATALINE SULPHATE AND BROMHEXINE HCl IN COMBINED DOSAGE FORM

Santosh V. Gandhi*, Mayuri Pansare, Nishant Kolhe, Bhagyashree Patil and Shruti Khandve

ABSTRACT

A simple, accurate and precise spectrophotometric methods has been developed for simultaneous determination of Terbutaline sulphate and Bromhexine HCl in bulk and in combined pharmaceutical dosage form. The methods developed were area under curve method and first derivative spectroscopy method using methanol as solvent. Regression analysis of beers plot showed good correlation range of 5-30 μg/ml for Terbutaline sulphate as well as for Bromhexine HCl. Proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Methods can be used for routine determination of these two drugs in combined dosage form.

Keywords: UV-Spectrophotometry, Terbutaline sulphate, Bromhexine HCl, Validation.


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