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Abstract

FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE ETHOSOMAL GEL

Saquib Raza Zahid, Surendra Dangi*, Shubham M. Shende, Neeraj Upmanyu

ABSTRACT

This research study was in aim to formulate and evaluation of ethosomes containing clindamycin phosphate by using phospholipid (0.5-1%), ethanol (10-30%), propylene glycol (20%) and distilled water by cold method. Prepared ethosomal vesicles evaluated for vesicular size, shape, entrapment efficiency, skin irritation and stability studies were carried out. Scanning electron microscopy and size analyser results showed that ethosomes were in spherical, unilamellar, nanometric size. The formulation F4 showed highest entrapment efficiency of 82.36±0.32% and vesicle size was found to 110±0.14. Then, optimized formulation of ethosomal vesicles (F4) was further formulated to gel by using carbopol (0.5-2%). EF2 was found to have shown excellent invitro drug release comparing gel containing free clindamycin drug and entrapment efficiency. Stability studies performed (EF2) at refrigeration temperature (4.0±0.2°C) and at room temperature (25-28±2°C) for 3 months. The kinetic study was found to be fit in zero order models and observed no remarkable symptoms on skin from skin irritation study. The present work also focuses on making the formulation more pharmaceutically acceptable.

Keywords: Clindamycin, Ethosomal gel, Phospholipid, Entrapment efficiency, stability studies.


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