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Abstract

SIMULTANEOUS ESTIMATION OF ARTEROLANE MALEATE AND PIPERAQUINE PHOSPHATE BY RP-HPLC

Chinna Vagya Naik Mudavath*, K. Thejomoorthy and P. Sreenivasa Prasanna

ABSTRACT

A simple, precise, reliable, rapid and reproducible reversed-phase high performance liquid chromatography method was developed and validated for the simultaneous estimation of Arterolane Maleate, Piperaquine phosphate Chromatography is carried out isocratically on Xbridge C18 (250 × 4.6 mm, 5μm)with a mobile phase composed of 0.1% OrthoPhosphoric Acid and Acetonitrile (in the ratio of 90:10 (v/v) at a flow rate of 0.9 ml/min. Detection was carried out using a PDA detector at 290 nm. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the ICH-Q2 (R1) guidelines. The retention times of Arterolane Maleate (ALM) and Piperaquine Phosphate (PQP) are 2.97, 6.97min respectively. The linearity range is 30-225 μg/ml for Arterolane and 150-1125 μg/ml for Piperaquine respectively. The correlation coefficients of ALM and PQP are 0.9975 and 0.9782. The proposed method can be useful in quality control of bulk Manufacturing and Pharmaceutical dosage forms.

Keywords: Arterolane Maleate and Piperaquine phosphate, HPLC, Validation, Retention time.


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