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Abstract

FORMULATION AND IN -VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF ESOMEPRAZOLE

*Eliza Subedi, Babita Mahato and Gajasher Rai

ABSTRACT

The main objective of the present work was to formulate mucoadhesive buccal tablets of an Esomeprazole drug using polymers by direct compression method and compare their effect on formulations to find the best polymer for the prepared formulations with better mucoadhesive property, better in-vitro dissolution profile and better in vitro drug permeation. Mucoadhesive Buccal Tablets of Esomeprazole were prepared by using polymers in different concentrations. Carbopol 934, HPMC K4M, guar gum and sod CMC were used as polymers. The tablets were subjected to the various parameters like hardness, thickness, weight variation, friability, surface pH, stability in saliva, in-vitro drug release, swelling index, bioadhesive strength and in vitro drug permeation. FTIR-IR study shows good compatibility between drug and other ingredients including polymers. In the present study all the powder blend showed good flow ability because all blends show angle of repose below 30°, bulk density in the range between 0.558 to 0.803 g/cm3, tapped density in the range between 0.629 to 0.979 g/cm3, and the compressibility index was found to be between 7.016 to 30.000 which ensures the blend that may be suitable for direct compression into tablets. In-vitro dissolution study for all tablets was performed and formulation (F8) containing sod carboxy methyl cellulose drug release of 102.021% within 4 hr. The assay range of eight batch was found to be 90 to 105%. In vitro drug permeation study for best formulation performed i.e. for F8 shows drug permeation of 101.045% within 4 hr.

Keywords: Esomeprazole, Mucoadhesive Buccal Tablet, carbopol 934, HPMC K4M, Guar gum, sod. CMC, Dissolution, Permeation.


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