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*Sanjita Das, D. Sasmal, S.P. Basu


Nyctanthus arbortristis Linn. (Family– Oleacea) is a well documented plant. Its various parts are used traditionally and in folk medicine for treating various diseases. The ethanolic extract of the leaves, seeds, bark and flowers (A, B, C and D respectively) were found to have the LD50 value more than 2.0 gm, whereas of arbortristoside-A was found to be 750 mg. The extracts and arbortristoside-A are also hematologically non toxic and have significant anti- inflammatory activity. The present study is aimed at formulation of the tablet dosage forms of extracted products (A, B, C, D) and arbortristoside-A and their bioavailability studies. The tablets were prepared by wet granulation method and subjected to standard evaluation process. The tablets were tested for dissolution rate using the USP paddle method. It was observed that the highest rate of release among the extracts was found with the products A and B (49 .6% and 59.0%) and minimum release rate was found from the extract of flower (20.1%), whereas that of arbortristoside-A was found to be 70%. For in-vivo bioavailability studies rats were used and were administered by the solutions of the tablets. The blood plasma data at different time intervals gave equivalent comparative results to that of the in-vitro study between the respective tablets. The system in the GI tract of rats delivered at the same rate as in-vitro which shows the in vivo test as a bioanalogus method predictive of the in-vitro performance of respective dosage forms. An in-vivo in-vitro correlation (IVIVC) for tablets of arbortristoside-A was established. The present study showed that the bioavailability of arbortristoside-A from its tablets is more than that of the extracts. It may be due to the presence of the chemical constituents other than arbortristoside-A, interfering its bioavailability.

Keywords: Bioavailability, Nyctanthus arbortristis L, arbortristoside-A.

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