Abstract

NEWER ANTIBIOTICS- A REVIEW

Dr. Laxmikanth Chatra, Dr. Saba Sayeed*, Dr. Prashanth Shenoy, Dr. Veena Km, Dr. Rachna Prabhu, Dr. Mariyam Zehra

ABSTRACT

Antibiotic therapy is an art and a science.Antibacterial drugs have revolutionized our ability to control bacterial disease, and their clinical availability has led to dramatic decreases in morbidity and mortality. It is difficult to draw a hard and fast line between what might be called the older antibiotics and the modern antibiotics. The incidence of antimicrobial resistance is on continued rise with a threat to return to the “pre-antibiotic” era. This has led to emergence of such bacterial infections which are essentially untreatable by the current armamentarium of available treatment options. Various efforts have been made to develop the newer antimicrobials with novel modes of action which can act against these multi-drug resistant strains. The development of resistant organisms too makes the availability of several antibiotics of great value. It is worth emphasizing too that resistance to the newer antibiotics tends to develop much more slowly than to some of the older ones and this may prove a great advantage. This review aims to focus on these newly available and investigational antibacterials approved after year 2000, their mechanism of actions/resistance, and spectrum of activity and their phases of clinical trials.

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