Abstract

GREEN SYNTHESIS OF BENZIMIDAZOLE DERIVATIVES: AN OVERVIEW

Pooja Devi*, Dr. Amit Chaudhary, Diksha Choudhary, Neha Sharma and Shalini

ABSTRACT

The chemical synthesis in our environment are increasing day by day. Advancements in chemistry have led to the production of medicines to alleviate our pain, polyester to keep us warm, fertilizers to provide our crops with nutrients. These same advancements have also generated numerous toxic chemicals, from the insecticides sprayed on our crops to the compounds found in water-based paints. Not only these are toxins harmful to our health, they are also damaging to the environment. Only some of them are degraded, but most of them are non-degradable. These non-degradable substances produce pollutions which cause instability, harm or discomfort to the ecosystem as pollutions and create a risk to the environment. To reduce the possibility of a system we must reduce the risk not by altering the effect but by the cause. Green chemistry is an approach that aims to eliminate the usage and generation of hazardous substances by designing better manufacturing processes for chemical products. Specifically, the goal of making the finished product and by-products less toxic. In recent years, various heterocyclic compounds have appeared owing to the extensive varieties of their pharmacological activities. Benzimidazole is considered as potential bioactive heterocyclic aromatic compound exhibiting remarkable pharmacological activities. It is an important pharmacophore and a privileged structure in medicinal chemistry. benzimidazoles are known to possess a varied range of pharmacological applications, namely, anti-cancer, anti-diabetic, anti-inflammatory, and antiviral like anti-HIV and anti-fungal. Because of its value, the processes for their synthesis have become a focus of synthetic chemists. Therefore, this review aims at compiling the chemistry of differently substituted benzimidazoles and some other methods. Conventional methods of synthesis need longer heating time, complicated and tedious apparatus set up which result in high cost and pollution in contrast to greener methods which are inexpensive.

Keywords: Benzimidazole, Green chemistry, Sustainable development.