Abstract

FLOATING DRUG DELIVERY SYSTEM

P. R. Wankhede*, S. B. Gondkar and Dr. R. S. Bachhav

ABSTRACT

Floating dosage forms are come out as a promising novel dosage forms. Floating dosage form can be prepared as tablets, capsules by introducing suitable excipients as well as adding certain gas generating agents. Which in turn give the dosage form in gastrointestinal excipients such as Poloxamer 188, Hydroxypropyl methyl cellulose, Polyvinyl Acetate, Alginate Beads and Casein Gelatin Beads in combination provide dosage form. The degree of drug introduce in dosage form determine its release. The hydrated layer releases the drug from the dosage form by diffusion. Due to the hydrated gel layer, floating dosage form can remain a float in stomach for 6-8 hrs. The release of pharmaceutical active ingredient are extended period of time in gastric environment. These systems have more flexibility in dosage design than conventional dosage form. The floating device such as Intelisite capsule can be used as it provides non invasive determination of drug absorption and bioavailability at specific sites.

Keywords: Floating drug delivery system, polymers, Evaluation in vivo and in vitro, single unit, multiple units.