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Abstract

RESPONSE OF SELECTED REPRODUCTIVE PARAMETERS & PROLACTIN LEVELS OF MALE ALBINO WISTAR RATS EXPOSED TO ANTIPSYCHOTIC DRUGS

Obemeata E. Oriakpono* and Chidera Anuforo

ABSTRACT

The effects of Antipsychotic Drugs; Haloperidol, Risperidone and Olanzapine on selected reproductive parameters and prolactin levels of male albino rats was Studied. A total of 32 healthy adult male wistar rats were used for the study, they were divided into 3 treatment groups and one control group exposed to the drugs at conventional doses considering body weights for 9 weeks. Biochemical analysis was carried out to determine the effects on semen parameters (percentage motility, sperm count, percentage morphology and percentage debris) and the hormone prolactin. In week 1, the highest percentage motility value was 78 in Olanzapine treated rats, sperm count and percentage morphology were at the least with values of 71 and 67 respectively in Haloperidol treated rats. Percentage debris and prolactin levels had higher values in the treated group compared to the control. In week 5, the percentage motility, sperm count and percentage morphology were at the least values of 63, 56 and 31 respectively in Haloperidol treated rats. The percentage debris was highest in Haloperidol treated rats with a value of 49 while prolactin level was highest in Olanzapine treated rats with a value of 55. In week 9, the lowest value of 44 and 40 were recorded for percentage motility and sperm count in Haloperidol treated rats while percentage morphology was least with a value of 40 in Risperidone treated rats. Percentage debris was highest in Haloperidol and Risperidone treated rats with the same value of 56. Prolactin level was highest with a value of 62 in Haloperidol treated rats. The results indicate that Haloperidol, Risperidone and Olanzapine have the potential to induce impotency, infertility while causing hyperprolactinemia associated with sexual dysfunction and impaired testosterone production in males.

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