WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR THE ESTIMATION OF CEFPODOXIME PROXETIL AND DICLOXACILLIN SODIUM IN TABLET DOSAGE FORM

Sneh N. Patel*, Kamlesh R. Prajapati and Professor Dr. Dhrubo Jyoti Sen

ABSTRACT

A simple, precise and accurate isocratic stability–indicating RP–HPLC method was developed and validated for the simultaneous determination of Cefpodoxime Proxetil and Dicloxacillin Sodium in commercial tablets. The method has shown adequate separation for Cefpodoxime Proxetil and Dicloxacillin Sodium from their degradation products. Separation was achieved on a Waters C18 (250 mm × 4.6 mm i.d., 5 μm particle size) column using a mobile phase consisting of Acetonitrile – 20 mM Ammonium Acetate Buffer (42:58 v/v) at flow rate of 1 mL/min and UV detection at 235 nm. This drugs were subjected to hydrolysis, oxidation, photolysis and heat to apply stress conditions. The linearity was investigated in the range of 5–25 μg/mL (r2 = 0.9993) for Cefpodoxime Proxetil and 12.5–62.5 μg/mL (r2 = 0.9991) for Dicloxacillin Sodium. The LOD were 0.10 μg/mL and 0.68 μg/mL for Cefpodoxime Proxetil and Dicloxacillin Sodium, respectively. The LOQ were 0.33 μg/mL and 2.06 μg/mL for Cefpodoxime Proxetil and Dicloxacillin Sodium, respectively.

Keywords: RP-HPLC, Cefpodoxime Proxetil, Dicloxacillin Sodium, Stability Indicating Assay Method.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More