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Abstract

FORMULATION AND EVALUATION OF OFLOXACIN IN-SITU GEL CONTAING MUCOADHESIVE POLYMERS

Vasia*, Shazia Iryn, Laxman Murthy G. and Shaik Sadik

ABSTRACT

In ocular delivery the physiological constraints imposed by the protective mechanisms of the eye lead to low absorption of drugs, resulting in a short duration of the therapeutic effect, poor bioavailability exhibited by these conventional eye drops. Thus the rapid precorneal elimination of the drug can be overcome by these in situ gelling systems that are instilled as drops into the eye and undergo a sol-to-gel transition in the cul-de-sac and improve the residence time of the drug in the eye is increased, bioavailability and patient compliance compared to eye drops. The purpose of the present research work was the optimization and evaluation of pH-induced ophthalmic in-situ gel of ofloxacin. The in-situ gel formulation was prepared by simple mixing method based on the pH triggering system by incorporation of various polymers like HPMC K10, HPMC K100 and Carbopol-940 in different proportions. The in-situ gel characteristics were evaluated for Clarity, gel pH, gel Capacity, Viscosity, sterility testing and in-vitro drug release studies. Optimization was done by using in-vitro diffusion study. The optimized formula showed no significant changes on stability studies when stored at 40ÂșC/75% RH for one month according to ICH guidelines.

Keywords: Ophthalmic in-situ gel, Ofloxacin, Carbopol-940, HPMC, HPMC K10,


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