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Abstract

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF VENLAFAXINE HYDROCHLORIDE

Swapnil D. Patil* and Ankita S. Patil

ABSTRACT

The main objective of this study was to formulate and evaluate the oro dispersible tablets of Venlafaxine Hydrochloride with natural, synthetic and co-processed superdisintegrants. Venlafaxine is known as a serotoninnor epinephrine reuptake inhibitor (SNRI) which is used in psychiatric disorders like depression, anxiety. Venlafaxine hydrochloridehas its oral bioavailability (40-45%) and biological half life (5-10 hrs). In the present study an attempt was made to formulate oral disintegrating tablets of Venlafaxine Hydrochloride with a view to achieve a better disintegration and dissolution rate and further improving the bioavailability of the drug. Orodispersible tablets were prepared using various concentrations (10%, 15%) of super disintegrants like Moringaoleifera, Crospovidone, Croscaramellose and co-processed excipients like 1:1 ratios of Moringaoleifera along with Crospovidone and Croscaramellose by direct compression method. The pre formulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters and the values were within prescribed limits and indicated good free flowing properties. The tablets prepared by direct compression method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in- vitro dissolution. Amongst all the prepared formulations, F7 which comprised of Moringaoleifera and Crospovidone 1:1 ratio at 10% concentration prepared by direct compression method was found to the best formulation as it exhibited satisfactory physical parameters, least disintegration time (21 sec), wetting time (27 sec) and highest % drug release i.e. (99.5%) at 30 minutes.

Keywords: Orodispersible tablet, Venlafaxine Hydrochloride, Super disintegrants, Moringaoleifera, Direct Compression method.


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