Abstract

ASSOCIATION BETWEEN CAROTID-INTIMA MEDIA THICKNESS AND TRIGLYCERIDE GLUCOSE INDEX IN HYPERTENSION

Shikha Sharma*, Pradeep Kumar Dabla and Nafija Serdarevic

ABSTRACT

Background: Hypertension is associated important risk factor for development of cardiovascular disease. Importance of high blood pressure is implicated for development of myocardial infarction and stroke. Similarly, carotid Intima Media Thickness (c-IMT) is found to be common tool for risk stratification for cardiovascular event due to atherosclerosis. Insulin resistance characterizes another mechanism responsible for underlying atherosclerosis in the absence of diabetes mellitus and hyperglycemia. Objectives: The present study was conducted to determine the effect of hypertension on Intima Media Thickness (IMT) of the common carotid artery with respect to triglyceride glucose index (TyG Index). Materials and Methods: Included consented patients aged more than 45 years who visited hospital for cardiac health check up. We enrolled 178 hypertensive and 66 normotensive subjects for carotid ultrasonography and health checkup. Results: The IMT of the common carotid artery and TyG Index were higher in the hypertensive individuals as compared to control (p = 0.002 respectively). Age, hypertension and TyG Index were important risk factors for increased c-IMT in CCA [odds ratio 1.10 (1.06-1.13); 1.24 (0.69-1.20) and 1.54 (0.70- 2.41) respectively. Conclusion: Age, hypertension and TyG Index were found to be associated with increased c-IMT. It is henceforth crucial to manage traditional risk factors in order to decelerate increase in cardiovascular disease incidence.

Keywords: Carotid intima media, Triglyceride glucose Index, Hypertension, Atherosclerosis, Insulin resistance.