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Abstract

DEVELOPMENT AND IN VITRO EVALUATION OF FUSIDIC ACID CONTAINING NIOSOMAL GEL FOR WOUND TREATMENT

Bhartendu Shukla*, Dr. Niraj Gupta and Shivam Sharma

ABSTRACT

NDDS are abiding to fulfill two criterions. Firstly, it should deliver the drug at a rate according to the body needs respective to the amount of treatment. Another criterion is it should deliver the active moiety to the targeted site. Conventional dosage forms including prolonged release dosage forms are restrained from meeting these prerequisites by various factors. Differing types of pharmaceutical carriers are available, such as particulate, polymeric, macromolecular and cellular entities. Particulate type carrier is known as a colloidal carrier system, including lipid particles, microspheres, nanoparticles, polymeric micelles, liposomes, niosomes, pharmacosomes, virosomes, etc. In the current study an attempt is made to prepare niosomal gel of Fusidic acid using various grades of surfectant such as Span 60 and Span 80. Among which Span 80 was seen to provide niosome formation. The pH of the prepared niosomal gel was found to be 7.23±0.025 7.34±0.02 respectively. Percentage drug content was obtained in all formulations with gel formation in a range of 76.21±0.065 to 87.84±0.051. The in vitro data indicated that pure drug showed 93% release within 6 hr. The drug release from the niosomal gel in desired range obtained in prepared formulation F8 which is 72.95±0.271% in 24 hr.

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