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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

A PROSPECTIVE STUDY OF ADVERSE DRUG REACTIOS DUE TO CHEMOTHERAPEUTIC AGENTS IN DIFFERENT CANCER PATIENTS

Basavanna P. L.*, Hanumanthachar Joshi, Albin M. Antony, Elisha Tom, Leenu Lakshmi and Muhammed Nabeel

ABSTRACT

Background: In cancer patients, early detection, evaluation and monitoring of adverse drug reaction are essential to reduce harm to patients and thus improve public health. Objectives: The main objective of the study was to assess adverse drug reactions due to chemotherapeutic agents in various cancer patients which help to detect the class of drug responsible for causing more number of Adverse Drug Reactions. Methods: The study was a prospective observational study which was carried for a period of 6 months in Bharath Hospital and Institute of Oncology, Mysore in all patients receiving chemotherapy. The study subjects will be monitored for adverse drug reaction and will be followed-up. A suitable designed data collection form will be used to collect all the necessary information. The clinical outcome of the patient is evaluated at the end of the study. Results: Out of 248 patients studied, 152 patients (61.2%) developed 250 ADRs. The major drug class responsible for producing ADR was found to be taxanes (35.9%) followed by platins (27.1%) and individual drug responsible was found to be paclitaxel. The most common type of ADR identified was Myelosuppression (21.6%) followed by hypersensitivity (11.6%) and alopecia (10.8%). Most of the ADRs were found to be probable (73.4%), moderate (68.8%), not preventable (78.8%) and predictable (95.2%). Conclusion: Results of this study further emphasized the need of Adverse Drug Reaction monitoring in a Day care chemotherapy department at cancer institute.

Keywords: Chemotherapy, Adverse Drug Reaction, Myelosuppression.


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