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  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL IMIDAZOLE DERIVATIVES FOR ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITY

Kundlik S. Khandare*, Laxman A. Chate, Suraj N. Wanjari, Megha P. Ambatkar and Pramod B. Khedekar

ABSTRACT

In the present research, 1, 2, 4-Trisubstituted-1H-imidazoles were synthesized by using nitrophenyl glyoxal with various substituted aryl aldehyde. The objective behind the research was to design and synthesize substituted imidazole derivatives and evaluates them for In vitro and In vivo anti-inflammatory and antibacterial activity. The purity and homogeneity of all the synthesized compounds were confirmed by their melting point, thin layer chromatography, UV spectrophotometry, and IR spectroscopy. In vitro anti-inflammatory activity of newly synthesized imidazole derivatives was carried out by protein denaturation method and In vivo anti-inflammatory activity was carried out by carrageenan induced rat paw edema method. Antibacterial activity was carried out by the cylinder (cup) plate method.

Keywords: Anti-inflammatory activity, Antibacterial activity, Imidazole, Substituted aryl aldehyde.


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