Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF FLURBIPROFEN

Vaishali A. Chaudhari*, Dr. Suraj M.Sarode, Prof. Bhushankumar S. Sathe, Dr.Gautam P.Vadnere

ABSTRACT

The objective of the study was to develop mucoadhesive buccal tablet of Flurbiprofen. Tablets of Flurbiprofen were prepared by direct compression method using mucoadhesive polymers like Carbopol 934P, HPMC K4M and Sodium Alginate in different ratios. Buccal tablets were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, swelling index, matrix erosion, surface pH, mucoadhesive strength, in vitro drug release, stability studies. The tablets were evaluated for in vitro release in pH 6.8 phosphate buffer for 10 hr in standard dissolution apparatus. Mucoadhesion strength was increased with increase in the concentration of carbopol. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi and Peppas diffusion model. Short-term stability studies on the promising formulations indicated that there were no significant changes in drug content, mucoadhesive strength and in vitro dissolution characteristics. IR spectroscopic studies indicated that there were no drugexcipient interactions. Stability of Flurbiprofen buccal tablet was determined by using pH 6.8 phosphate buffer absorbance was measured for 96 hrs and it was found that buccal tablet were stable in pH 6.8 phosphate buffer.

Keywords: Mucoadhesive buccal tablet; Flurbiprofen; Swelling index; Mucoadhesive strength; Carbopol 934p; Formulation; Evaluation.