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Monali G. Kalbhor*, Meera A. Deshmukh and Dr. Pranati Tilak


The main objective of the present investigation is to improve the dissolution rate, aqueous solubility & preparation of immediate release tablets of Telmisartan. Liquisoild compact were prepared using olaic acid as nonvolatile solvent, microcrystalline cellulose, Neusilin US2, Fujicalin SG as a carrier material and aerosil 200 as a coating material in different ratio. Telmisartan was formulated in form of liquisoild compact in different R value: 10, 12. The effect of carrier: coating ratio on the in-vitro dissolution characteristics at two different dissolution media like HCL pH 1.2 and phosphate buffer pH 6.8 was studied and rate of drug release compared with marketed formulation. The prepared liquisolid compact were evaluated for the flow properties, DSC, XRD, FTIR. The formulated liquisolid compacts were mixed with a superdisintegrant (sodium starch glycolate), lubricant(magnesium sterate) and compressed in to tablets (lsc1-lsc6) and were evaluated for various post compression parameters like hardness, friability, weight variation, content uniformity, disintegration time, wetting time. Also, in vitro drug dissolution study was carried out.[1,2] The dissolution studies of a optimized formulation (lsc-4) compaired with marketed preparation were carried out, and it was found that lsc-4 showed significant higher drug release rate than marketed preparation.[3] Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption. From this study it was concluded that the liquisolid technique is more effective approach to enhance the dissolution rate of telmisartan.

Keywords: liquisolid compact, neusiline US2, fujicaline SG.

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