Abstract

DEVELOPMENT AND IN-VITRO EVALUATION OF KAPPA CARRAGEENAN BEAD FOR SUSTAINED DELIVERY OF REPAGLINIDE

Priya Kumari*

ABSTRACT

Controlled drug delivery system release drug at predetermined rate to sustain a consistent drug concentration for a fixed period of time with less side effect. Repaglinide is a low dose drug taken just before meal to minimize the amount of post– prandial blood glucose by reducing blood glucose by stimulating the release of insulin from pancreas working on β cells. Repaglinide is safe alternative for diabetic patient with compromised kidney function as excreted almost entirely through bile. To preserve Therapeutic plasma concentration of repaglinide and remove its adverse effect especially Hypoglycemia, kappa carrageenan beads is used to develop control and sustained drug delivery system. Kappa-carrageenan is used as a trapping medium for drugs and enzymes. Formulation of micro beads is done by Inotropic Gelatin process. In hydrochloric acid (0.1N) and phosphate buffer pH 7.4 using dissolution test apparatus, optimized drug release formulation in vitro was studied. In vitro data was fitted to zero order, first order, model Higuchi and Korsmeyer-Peppas to learn drug release rate and mechanism. The Korsmeyer-Peppas model explains that Repaglinide followed a process for regulating the release of microbead release control mechanism This system overcome risk of alkaline microenvironment as generated earlier like by using gastro retentive drug delivery systems.

Keywords: Nano-Controlled Drug Delivery, Preformulation study, PH of the Patch, Kapa carragenan Beads, In vitro Drug Release Study.