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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

A PROSPECTIVE OBSERVATIONAL STUDY IS TO EVALUATE THE ADVERSE EVENTS ON MEDICAL MANAGEMENT OF PATIENTS WITH CHRONIC PANCREATITIS

Menga Keerthana*, Misbah Unnisa, Rupjyoti Talukdar and A. Srinivasa Rao

ABSTRACT

Background: Chronic pancreatitis is the inflammation of the pancreas. It is a chronic process that causes irreversible structural and functional changes causing: pain, weight loss, and maldigestion thus declining the Qo2, its signs and symptoms is variable depending on the stage of the disease. Aim: The present work aims to evaluate the adverse events of medical management in patients with chronic pancreatitis. Objectives: To collect the demographic details of the patients receiving chronic pancreatitis treatment. To evaluate the adverse events of medical management in patients with chronic pancreatitis. To identify the incidence and patterns of adverse reactions associated with the use of drugs in chronic patients. To assess the severity of ADRs by the Naranjo scale. Materials and Methodology: The study was conducted in the Asian Institute of Gastroenterology Hospital, Gachibowli, Hyderabad. This subject is observational and the subjects enrolled under this study were about 70 informed consent was obtained. Subjects involved in the study were outpatients in the hospital. The causality assessment of suspected ADEs was performed using the Naranjo scale. Results: This study identifies the incidence and patterns of ADEs in patients who have prescribed the therapy for chronic pancreatitis in which male patients (75%) were more prone to the occurrence of ADEs when compared with the male patients (25%). based on the occurrence of single or multiple ADEs, more no. Of patients were associated with multiple ADEs (75%) than the patients affected with single ADEs.More number of patients was having probable reactions (46.8%) and followed by possible reactions (21.8%),doubtful (15.6%) and definite (15.6%) were identified using Naranjo scale. Conclusion: A total of 70 patients were observed who are undergoing the treatment for chronic pancreatitis. Major ADEs in chronic pancreatitis therapy can cause significant morbidity. These events may result in substantial additional costs because of added output visits, investigations, and in more serious circumstances hospitalization. Regular ADE monitoring is required to reduce morbidity. This study needs to be evaluated for further research to identify the several adverse events associated with medical management like Antioxidants and pancreatic enzymes replacement therapy (PERT) in chronic pancreatitis (CP).

Keywords: Chronic pancreatitis, adverse drug events, Antioxidant, PERT.


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