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  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

DEVELOPMENT AND EVALUATION OF ENTERIC COATED FORMULATION OF CHLOROQUINE DIPHOSPHATE

*Ashish Kumar Pandey1, Parmanand Verma1, J.S. Dangi2, A. K. Jha1, R. N. Gupta3

1Faculty of Pharmaceutical science, shri shankaracharya group of institute, Bhilai, India
2S.L.T. Institute of Pharm. Sciences Bilaspur (C.G.) India
3Birla institute of technology Mesra, Ranchi (JH) India

ABSTRACT

Objective and background- The challenge in pharmaceutical research is the development of site specific dosage forms that release active ingredients at the site of absorption (e.g. intestine or colon). The enteric coated dosage forms are usually developed to overcome problems such as gastric irritation, drug stability in gastrointestinal tract, poor absorption or permeability and incompatibility with other drugs. Enteric dosage forms can be prepared by using aqueous coating, organic solvent based coating, latex system and incorporation of enteric co-filler. Some antimalarial and other drug cause gastrointestinal irritation leading to nausea vomiting and diarrhea which cause a lot of inconvenience to the patient under antimalarial drug therapy for better compliance enteric coated formulation are best. Material and method- In enteric coated formulation of Chloroquine diphosphate were designed with a view to enhance patient compliance by granulation and dip coating method. The granules, prepared by the wet granulation, were subjected to physical characterization and in vitro drug release studies. Observation- DSC thermogramme of Chloroquine diphosphate showed an exothermic peak with and onset from194.32C to reach a maximum peak at 192.32C. Structure of CAP and Chloroquine diphosphate was confirmed by identification of their functional groups on interpreting their FTIR. The in vitro drug release study was carried out using USP apparatus 1at 100 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 2 hrs, followed by 900ml alkaline dissolution medium (pH 6.8). The drug release rate was strongly influenced by the concentration of polymer. To analyze the release mechanism higuchi, zero-order, first-order, hixson-crowell, and korsmeyer-peppas model were used.

Keywords: enteric coated, formulation, DSC thermogramme.


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