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Abstract

BIO-EQUIVALENCE STUDY OF TWO ORAL DOXYCYCLINE FORMULATIONS (DOXYLIN® AND DOXYGO®) IN BROILER CHICKENS

Ashraf El-Komy* and Mohamed Aboubakr

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Doxylin® and Doxygo® in healthy broiler chickens after oral administration of both products in a dose of 20 mg doxycycline base/kg.b.wt. Twenty four broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Doxylin®, while the 2nd group was designed to study the pharmacokinetics of Doxygo®. Each broiler chickens in both groups were orally administered with 20 mg doxycycline base/kg.b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration The disposition kinetics of Doxylin® and Doxygo® following oral administration of 20 mg doxycycline base/kg.b.wt. revealed that the maximum blood concentration [Cmax] were 3.93 and 3.81 μg/ml and attained at [tmax] of 1.04 and 1.07 hours, respectively. In conclusion: Doxygo® is bioequivalent to Doxylin® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) was 0.96, 0.95 and 0.92 respectively. These are within the bioequivalence acceptance range. Doxygo® and Doxylin® are therefore bioequivalent and interchangeable.

Keywords: .


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