Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

SILYBUM MARIANUM SEEDS EXTRACT AMELIORATES OXIDATIVE STRESS AND APOPTOSIS IN DIABETIC RATS

Alshimaa M. Abobeah, Om Ali Y. El-Khawaga, Amira O. Abd El-Azim, Amira Awadalla and Amr Negm*

ABSTRACT

Silybum marianum is a well known herbal medicine for its therapeutic benefits in complementary medicine. Thus, this study will shed the light on the effect of SM seeds extract on various disorders and complications in biochemical markers of glycemic status, apoptosis, and oxidative stress associated with diabetes. After diabetes induction, crude Silybum marianum seeds (SM) extract (250 mg/kg) was given to both diabetic and normal groups for 30 days. Then, biochemical, molecular and histopathological changes was evaluated. Results: Oral administration SM extract significantly decreased serum glucose, HbA1C and increased serum insulin. Furthermore, upon treatment, an increase in the antioxidant enzymes and a decreased level of MDA was noticed. On the other hand, the treatment reduced the Mrna expression of hepatic Nrf-2, HO-1, pancreatic Glucokinase, bcl-2, and increased Bax mRNA expression. Moreover, SM extract restored the histopathological changes of pancreas, which confirmed the biochemical findings. Discussion and Conclusion: crude SM seeds extract exhibits hypoglycemic activity through modulation of oxidative stress and apoptosis inhibition.

Keywords: Silybum marianum, Diabetes, Hypoglycemic agents, Antioxidants, Apoptosis.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More