Abstract

FORMULATION AND EVALUATION OF MATRIX TRANSDERMAL PATCH OF TIZANIDINE HYDROCHLORIDE

Bhambar Kunal V.* and Dr. Pande Shrikant D.

ABSTRACT

Tizanidine Hydrochloride is used to control of spasticity as muscle relaxant. Tizanidine Hydrochloride is white crystalline powder. Tizanidine hydrochloride stimulate adrenergic receptors in the central nervous system and inhibiting presynaptic release of nor- epinephrin and increasing the inhibitory effect on alpha motor neurons and motor reflexes. In the present investigation, efforts were put to develop a transdermal patch of Tizanidine Hydrochloride. Transdermal drug delivery system has ability to deliver drug into systemic circulation and by passing the liver which increase the bioavailability of the drug. Transdermal patches were prepared by using mercury substrate method. Eudragit RL and Ethyl cellulose were used to retard the drug release. Transdermal patches were evaluated for different quality attributes. In vitro drug release showed that polymer percentage is enough to extend the release of the drug for at least 12 hr. The dissolution curve shows that formulation TDDS F3 shows maximum drug release i.e. 80.54 % while TDDS T1 shows least i.e. 65.87 % at the end of 12 hours.

Keywords: Transdermal Patch, TDDS, Eudragit RL, Ethyl Cellulose, Tizanidine Hydrochloride.