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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE MIGLITOL MICROSPHERES

Nalluri Mary*, A. Naganjaneyulu, K. Thejomoorthy and P. Sreenivasa Prasanna

ABSTRACT

The aim of the present work is to provide a therapeutic amount of Miglitol site in the body and also to achieve and maintain the desired ISD concentration. Miglitol having 2 hour half-life and low bioavilability. In the present study nine formulations were formulated by using HPMC K15M, Ethyl cellulose and karaya gum in different proportions. The FTIR Spectra revealed that, there was no interaction between polymers and Miglitol. As the polymer ratio was increased, the mean particle size of Miglitol microspheres was also increased. From the results it can be inferred that there was a proper distribution of Miglitol in the microspheres and the deviation was within the acceptable limits. On the basis of release data and graphical analysis formulation F9 containing HPMC K15M showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism.

Keywords: Miglitol, Ethyl Cellulose, HPMC K15M, FTIR and Karaya gum.


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