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Abstract

FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ACYCLOVIR

*Sandip B. Sapkal1, Mahesh B. Narkhede1, Gautam D. Mehetre1, Prasad V Rane2, Amit M.Pant3

1Department of Pharmaceutics, IBSS College of pharmacy, Malkapur, Dist. Buldana, India
2Department of Pharma chemistry, Rajmata jijau shikshan prasarak mandal, Pune, India
3Department of Pharma chemistry, RTMNU, Nagpur, India

ABSTRACT

The aim of present study was to design and formulate the gastroretentive floating tablet of acyclovir by direct compression method. Floating tablets of Acyclovir were prepared by employing three polymer viz. HPMC K100 M, HPMC K15 M and Carbopol 934P by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas-generating agent. Floating polymers used alone or in combination in formulation. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The floating behavior and in vitro dissolution studies were carried out in a USP 23 apparatus 2 in 0.1 N Hcl. All the seven batches (F1-F7) showed good in vitro buoyancy. F7 formulation showed maximum floating time of 24 hours and gave slow and maximum drug release of Acyclovir spread over 24 hours. Optimized formulation F7 contained all HPMC K100 M, HPMC K15 M and Carbopol 934P. F7 formulation showed no significant change in physical appearance, drug content, floatability or in vitro dissolution pattern after storage at 45 C/75% RH for two months.

Keywords: Acyclovir, gastro retentive floating tablet, Carbopol 934P, Stability studies.


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