Abstract

SYNTHESIS OF SOME NOVEL 4, 6-DISUBSTITUTED DERIVATIVES OF QUINAZOLINE, AND EVALUATION OF THEIR ANTI-INFLAMMATORY ACTIVITY

*Rama Kant and Dr. Harpreet Singh

ABSTRACT

In view of the link between use of NSAIDs and altered anti-inflammatory agents and a growing evidence of COX-II implications in angiogenesis, a novel series of 4, 6-substituted quinazoline derivatives have been synthesized starting from anthranilic acid derivatives through conventional methods. Initially acylation followed by cyclisation to obtain benz-oxazinones which on further treatment with ammonia yielded the crucial intermediate, 2-substituted benzamide. The products were subsequently cyclised to obtain quinazolones, chlorinated, then hooked to have various 4, 6-disubstituted quinazoline derivatives. All the derivatives are screened for anti-inflammatory activity.

Keywords: Anthranillic acid; Angiogenesis; Amination; Chlorination.