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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF METRONIDAZOLE, FURAZOLIDONE AND DICYCLOMINE HYDROCHLORIDE IN TABLET DOSAGE FORM BY HPTLC

Dhimmar Maitri N.* and Dr. Narkhede Sachin B.

ABSTRACT

A new simple High performance thin layer chromatographic method was described for the analysis of Metronidazole, Furazolidone and Dicyclomine hydrochloride in tablet dosage form. The method employed a HPTLC aluminium plates precoated with Silica gel 60F254 as the stationary phase and mixture of Methanol : Chloroform : Triethylamine (2.5:7.5:0.1) as mobile Phase. The densitometric evaluation of separated bands were stained with Iodine vapours and scanned at 274 nm. The Rf values of Metronidazole, Furazolidone and Dicyclomine hydrochloride 0.73, 0.44 and 0.34 respectively. Calibration curve were linear in range of 100-800ng/spot for Metronidazole, 250-2000ng/spot for Furazolidone and 30-240ng/spot for Dicyclomine hydrochloride. The percentage recovery was found to be 99.45-100.16%, 99.95-100.32% and 99.02-100.25% for Metronidazole, Furazolidone and Dicyclomine hydrochloride respectively.

Keywords: High performance thin layer chromatography, Metronidazole, Furazolidone and Dicyclomine hydrochloride, Validation.


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