Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

DEVELOPMENT OF VALIDATED CHIRAL RP-HPLC-PDA METHOD FOR THE ESTIMATION OF CETIRIZINE ENANTIOMERS IN BULK AND DOSAGE FORMS

Buchi N. Nalluri*, M. Lakshmi Prasanna and Tharun Kumar B.

ABSTRACT

A simple and precise chiral reverse-phase high pressure liquid chromatographic method was developed to separate and estimate the enantiomeric forms of Cetirizine (CET) in bulk and dosage forms. Chiral analysis was performed on Phenomenex Lux Cellulose-4 column (250×4.6mm, 5μ) using 0.02% Trifluoro acetic acid: Acetonitrile (72:28 v/v) as mobile phase at 1mL/min flow rate. The eluents were monitored at 230nm using PDA detector with an injection volume of 20μL. The retention times for CET enantiomers L and D were 10 and 12 minutes respectively with good peaks resolution and showed good linearity in the concentration range of 10-50μg/mL (R2>0.999). The limit of detection and limit of quantification were found to be 0.002μg/mL, 0.0062μg/mL for L-CET and 0.010μg/mL, 0.032μg/mL for D-CET respectively. The developed method was validated as per International Conference on Harmonization guidelines and successfully applied for the enatioselective analysis of CET in bulk and dosage forms.

Keywords: Chiral separation, Cetirizine, Reverse phase HPLC, PDA detector.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More