Abstract

TO FORMULATE AND EVALUATE POLYHERBAL TABLET FOR ANTIUROLITHIATIC ACTIVITY

Jyotirmoy Bhattacharyya*, Sidhartha Jyoti Bora, Suman Jyoti Sarmah, Rupjyoti Kalita and Violina Kalita

ABSTRACT

Urolithiasis is when a solid piece of material occurs in the urinary tract. Kidney stones typically form in the kidney and leave the body in the urine stream. A small stone may pass without causing symptoms. If a stone grows more than 5mm, it can cause blockage of ureter resulting in severe pain in the lower back or abdomen. A stone may also result in the blood in urine, vomiting, or painful urination. The present study aims to formulate and evaluate polyherbal tablet for antiurolithiatic activity. Polyherbal tablet was formulated by using extracts of C. Sinensis, H. rosa sinensis, Tribulus terrestris and Puica granatum extract. The tablets were tested for the physical properties: such as appearance, weight variation, friability, tablets thickness, tablets hardness, and disintegration time. The homogenous precipitation method was used for in vitro antiurolithiatic activity. The percent inhibition of calcium oxalate precipitated by the test (combined extract) was calculated in comparison with the control and standard (Cystone) samples. The herbal tablet formulation of C. Sinensis, H. rosa sinensis, Tribulus terrestris and Puica granatum have shown an inhibitory effect on calcium oxalate precipitation thus may be beneficial in the treatment of urolithiasis. This effect may be due to the presence of phytochemicals like polyphenols, flavonoids, and saponins, etc.

Keywords: Urolithiasis, Polyherbal, Antiurolithiatic, Cystone, Calcium oxalate.