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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL COMPOUNDS OF 3-(((1H-BENZO [D]IMIDAZOL-2-YL)METHYL)AMINO)-1-(2,5-DIFLUOROBE NZOYL)-4-(2-PHENYLHYDRAZONO)-1H-PYRAZOL-5(4H) -ONE

M. Swarna Kumari*, K. Udaya Kumari, K. Sudhakar Babu and L. K. Ravindhranath

ABSTRACT

New novel derivatives of 3-(((1H-benzo[d]imidazol-2-yl)methyl)amino)-1-(2,5-difluorobenzoyl)-4-(2-phenylhydrazono)-1H-pyrazol-5(4H)-one (4a-g) were prepared by refluxing of ethyl 2-(4-(2-(4-subtituted methyl)phenyl) hydrazono)-1-(2,5-difluoro benzoyl)-4,5-dihydro-5-oxo-1H-pyrazol-3-yl)amino Carboxylic acid. (3a-g)Orthophenylene diamine, Cyclo hexane and ethyl acetate. The synthon 3a-g were synthesized by refluxing a mixture of ethyl 2-((1-(2, 5-difluorobenzoyl)-5-oxo-4-(2-phenyl hydrazano)-4, 5-dihydro-1H-pyrazol-3-yl) amino) acetate and tetra hydro furan. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectra & Elemental analysis. The newly synthesized compounds were screened for their Biological activity.

Keywords: Benzimidazoles, Ortho phenylene diamine, Antibacterial and Antifungal activity, spectral data.


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