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Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LOSARTAN POTASSIUM

R. Vara Lakshmi, S. Venkateswara Rao, B. Hemalatha* and K. Padmalatha

ABSTRACT

The present focus is on the development of sustained release formulations due to its inherent boons. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance, reduction in fluctuation and increased safety margin of potent drug. The present study was aimed to prepare a floating drug delivery system to design a controlled release oral dosage form of Losartan Potassium. This helps to overcome the demerit of limited residence time of the drug in the gastrointestinal track and hence to increase the duration of release. The floating delivery system of Losartan potassium by direct compression method with starch urea borate was prepared and evaluated for different parameters such as weight uniformity, thickness, hardness, friability, swelling index, buoyancy studies and In vitro release studies. The in vitro dissolution study was carried out for 12 hours using USP (Type- II) paddle apparatus in hydrochloride (0.1N) as dissolution media. Mean dissolution time was used to characterize drug release rate from a dosage form which indicates the retarding efficiency of polymer. Based on the in vitro dissolution data, formulation F6 was selected as the best formulation from Losartan potassium formulations (F1 – F6) respectively, the drug was retarded up to 12 hours with 82.88% and followed first order release kinetics.

Keywords: Starch urea borate, Direct Compression, Floating Matrix Tablet and In vitro Dissolution.


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