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Abstract

FORMULATION & EVALUATION OF PROLIPOSOME OF ELETRIPTAN HYDROBROMIDE BY USING SOLVENT EVAPORATION TECHNIQUE

Sachin Bhusari*, Bharti Gotmare and Pravin Wakte

ABSTRACT

The aim of present study is develop and evaluate Eletriptan Hydrobromide pro- liposome powder oral drug delivery system. Pro-liposome are phospholipids-based drug delivery system. Proliposomes prepared using solvent evaporation technique by varying lipid phase (Phosphatidylcholine/ cholesterol) and Mannitol composition. It promotes drug absorption, increases the efficacy and therapeutic index of drug and also increases stability via encapsulation, biocompatible, biodegradable and non-toxic. Proliposomes formulation was characterized for entrapment efficiency, drug content, surface morphology, number of vesicles. Followed by In-vitro release studies. Oral pro- liposome powder showed good properties with angle of repose was less than 30, Car‟s index and Hausner‟s ratio were also less than 21 and 1.25, respectively. The mean size of the vesicle was in the range 180-290 nm. the assay and entrapment efficiency of proliposomes formulation were 74.89±0.4 to 95.89±0.7%, respectively. In vitro release of EHbr proliposome powder formulation was 94.25±o.4 after 24 hrs which shows good release from the vesicle of proliposome. In vitro studies carried out provides an insight on the stability and enhances dissolution of from Proliposome formulation. The solid state characterization like SEM, FT-IR, DSC studies of Eletriptan Hydrobromide Proliposome were carried out.

Keywords: Eletriptan Hydrobromide, bioavailability, Phosphatidylcholine, Box-Behnken design.


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