WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

EFFECT OF FEW FORMULATION VARIABLES ON ENTRAPMENT EFFICIENCY OF SILVER SULFADIAZINE NIOSOMES

Sanket Dharashivkar*, Sangeeta Sahasrabuddhe and Ashok Saoji

ABSTRACT

Conventional formulation of silver sulfadiazine (SSD) available in market has been shown to decrease wound-related infections and morbidity in burn wounds but required to be applied two to four times a day. Niosomally encapsulated SSD can prove beneficial to obtain a sustained release. SSD is not soluble in most of the polar and non polar solvents. Therefore, the objective of this study is to investigate the effect of organic and aqueous solvents used in the manufacturing of niosomes and some other formulation variables on the entrapment efficiency of SSD. Niosomes were developed by ethanol injection methods using span 60 and tween 60 with cholesterol. Formed niosomes were evaluated for entrapment efficiency, vesicle size, photomicroscopy, in vitro release, scanning electron microscopy, in vitro antimicrobial activity and stability. Different formulation factors were found to affect the entrapment efficiency. Optimized niosomes had shown the sustained release of 98.14 % over 28 hours. In vitro antimicrobial study using Staphylococcus aureus revealed that the niosomal formulation of SSD shows a better zone of inhibition (16 mm) in comparison to conventional dosage form (14 mm) even when used in half the concentration of conventional dosage form.

Keywords: Silver sulfadiazine, burn treatment, antimicrobial study, entrapment efficiency.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More