Abstract

FORMULATION AND EVALUATION OF MATRIX TABLETS OF QUETIAPINE FUMARATE

Uday K. Arya*, Dr. H. D. Karen and Dr. P. H. Prajapati

ABSTRACT

The psychiatric illness treatment frequently requires long-term treatment. A number of innovative dosage forms and delivery systems have been developed in order to compensate the important issues that lead to suboptimal treatment outcomes, many of which are related to partial and noncompliance with medication. These technologies strive to enhance drug delivery, assure efficacy, and reduce the potential for side effects. Quetiapine fumarate (QTP) is antipsychotic drug having short half-life of 6 hours. Also drug molecule is well absorbed throughout gastrointestinal tract. Hydrophilic polymer matrix systems are widely used in oral controlled drug delivery because they make it easier to achieve a desirable drug-release profile, they are cost effective, and they have broad USFDA acceptance. The hydrophilic polymer matrix system consists of hydrophilic polymer, drug and other excipients distributed throughout the matrix. This dynamic system is dependent on polymer wetting, hydration, and dissolution for controlled release of drug. At the same time, other soluble excipients or drug substances will also wet, dissolve, and diffuse out of the matrix, whereas insoluble excipients or drug substances will be held in place until the surrounding polymer, excipients, or drug complex erodes or dissolves away. The polymer based monolithic matrix is one of well-known approach to make sustained or extended release solid dosage form for drug. Presently in this work hydrophilic glassy polymers were used to prepare once a daily monolithic matrix. The different grade of Hydroxypropyl methyl cellulose (HPMC) like HPMC K4M, HPMC K15M were used as hydrophilic polymers.

Keywords: HPMC K4M, HPMC K15M, Quetiapine fumarate.