Abstract

STRATEGEM FOR OPTIMIZATION AND APPRAISAL OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM

Smita Nayak*, Siddhesh Kamble and Bhaskar Vaidhun

ABSTRACT

Over the past few years, nanotechnology has greatly influenced drug delivery research and many nanoscale technologies have been explored to improve the therapeutic efficacy of the drugs. Self-nanoemulsifying drug delivery systems (SNEDDS) are homogenous liquid mixtures consisting of oil, surfactant(s), co-surfactant(s) and drug which, when diluted with aqueous solutions spontaneously form oil-in-water nanoemulsion having globule size of approximately 200 nm or less. Appropriate selection of the oil, surfactant and co-surfactant dictates the behavior of the drug in vivo. Drugs with limited solubility when incorporated in this dosage form have outclassed conventional dosage forms. This review unravels the complexities of SNEDDS and provides a road map for keen researchers looking for simple effective strategies to overcome solubility challenges.

Keywords: Self nano-emulsifying drug delivery system, nano-emulsion, co-surfactant, emulsification time, percent transmittance, cloud point.