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Abstract

NOVEL ORAL DELIVERY FLOATING IN-SITU GEL: DEVELOPMENT AND CHARACTERIZATION STOMACH SPECIFIC DELIVERY FOR GASTRIC ULCER THRU AMOXICILLIN TRIHYDRATE

Tushar Verma*

ABSTRACT

The spark scientific investigation study novel delivery floating in-situ gelling system for stomach specific delivery gastric ulcer thru amoxicillin trihydrate is achieved specific site oral controlled drug delivery system under the specific manner of formulation. The felicitous design of in-situ gel dosage regimen is important of execute this goal and the drug amoxicillin achieved a steady state blood plasma level that is therapeutically effective and nontoxic for an extended period of time. The whole entity development of polymeric in-situ gel execute with Sodium Alginate, Sodium Citrate and HPMC under heated to 60°C with stirring than below 40°C another specific quantity of deionized water containing HPMC using it under gelling principle of Sodium alginate the free Ca2+ entrapped in polymeric chain. The active drug amoxicillin is a semi-synthetic aminopenicillin, with a broad-spectrum bactericidal activity 1-5, used as trihydrate in oral delivery, an effective anti H. Pylori drug. A gastro-retentive drug delivery system of amoxicillin development for enhanced residence time in stomach and achieved site specific prolonged absorption the different formulation concentration of amoxicillin using in-situ gel polymeric condition with scientific laboratory numbering F1 to F6. In the all formulation determination of active dosage with FT-IR study under interaction between drug and polymers and purity of drug. The in-situ gelling capacity optimized with different concentration (2%, 3%, 4%) of sodium alginate and sodium citrate and the drug release percentage optimized 12 hours in different concentration in specific time interval the determination of controlled release amoxicillin entrapment in-situ gelling system optimized by chrono-pharmacokinetic models. All the six formulations stability study done according ICH guidelines were subjected to stability studies at ambient humidity conditions at 20°C to 80°C, ambient temperature and 40±10°C for a period of one month under day wise interval. Formulation F-4 showed excellent percentage drug release, gelling capacity, and floating time as compared to other formulations.

Keywords: In-situ gel, Oral controlled drug delivery, Stomach specific delivery, H. Pylori, Amoxicillin trihydrate, Sodium Alginate, Sodium Citrate, Hydroxylpropyl methylcellulose, Chrono-pharmacokinetic.


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