Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

FORMULATION AND DEVELOPMENT OF ZILEUTON ALBUMIN MICROSPHERES

Rudroju Anusha*, Dr. V. Swapna, B. Anusha, B. Pranitha, B. Shirisha and B. Soundarya Rani

ABSTRACT

Albumin microspheres loaded with zileuton have been selected as a basis of the research work because major plasma protein constituent accounting for 35.5% of the total protein in human plasma is albumin. Albumin microspheres are investigated in control release system as vehicles for the delivery of therapeutic agent to local sites. As it is a natural polymer which is biodegradable, lacks toxicity and non-antigenic in nature.. Therefore, the use of this carrier system is the targeting of anti-asthmatic drugs in the treatment of, asthma. In this study, microspheres of an anti-asthma drug will be developed using egg albumin. Zileuton is an anti asthma drug that differs chemically and pharmacologically from other anti-asthmatic agents. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway. To develop albumin microspheres, certain preparation methods like chemical cross-linking method, single emulsion polymerization method, emulsification-heat stabilization methods will be adopted. The selection of best formulation will be based on the results demonstrating the particle size, surface morphology, loading efficiency, % yield value, thermal behavior, physical characteristics, swelling properties, and the invitro release profile.

Keywords: Controlled release, polymerization, cross-linking, microspheres, Surface morphology, Fourier transform infrared, Differential scanning calorimetry, In vitro release kinetics.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More